Cellular Therapy Fellowship

This is a training position for an aspiring pathologist in the rapidly expanding field of cellular therapy. The candidate will work at the campuses of both the Hospital of the University of Pennsylvania (HUP) and the Children’s Hospital of Philadelphia (CHOP), with three current Good Manufacturing Practice (cGMP) facilities: the Clinical Cell and Vaccine Production Facility (CVPF) at Penn, the Cell and Gene Therapy Laboratory (CGTL) and the Clinical Vector Core (CVC) both at CHOP.

The cellular therapy activities at HUP and CHOP cover the entire range of standard-of-care adult and pediatric bone marrow transplant, from collection to processing to infusion. The cGMP facilities also engage in a large number clinical trials under Investigational New Drug or Device Exemptions (IND/IDEs) approved by the FDA, some of which are in collaboration with third party industrial sponsors.

Examples of these IND/IDEs include the manufacturing of Chimeric Antigen Receptor T cells, virus specific cytotoxic T lymphocytes, and selective T/B cell depleted transplant grafts. The candidate will have a wide exposure of different cGMP labs all within walking distance, learn the set up and operation of cGMP facilities, in addition to the actual manufacturing processes.